Now Foods, Glycine Capsules, 1000 mg, 100
- Needed to Produce a Powerful Antioxidant.
- A Component of Creatine.
- The Main Amino Acid in Collagen.
- May Improve Sleep Quality.
- May Protect Your Liver From Alcohol-Induced Damage.
- May Protect Your Heart.
- May Aid People With Type 2 Diabetes.
- May Protect Against Muscle Loss.
Description
Glycine is an amino acid and neurotransmitter. It acts as a stimulus and inhibitor in the brain. Supplementing it can improve sleep quality.
Glycine is a conditionally essential amino acid discovered by the French chemist Henri Braconnot in 1820 by acid hydrolysis of gelatin. Glycine is the simplest amino acid in nature, having a single hydrogen atom as its side chain. Glycine is as sweet as glucose, and its name comes from the Greek word glykys (meaning sweet).
On stable antipsychotic therapy, schizophrenia patients were treated with 800 mg/kg glycine daily for 6 weeks, and supplementation was noted to be associated with a 23+/-8% reduction in negative symptoms, but less effect on cognition and positive symptoms Difference.
Among female participants who were given 3 g of glycine 1 hour before bedtime, more self-reports of reduced fatigue in the morning and improved sleep quality were reported than placebo. Glycine has been reported to improve subjective sleep quality associated with shortened sleep latency and time to slow-wave sleep (REM sleep and overall sleep architecture were not affected). A later study also demonstrated improved cognitive daytime performance associated with better self-reported sleep, and it has been confirmed.
In a 7.4-year follow-up, plasma glycine concentrations were significantly associated with an 11% lower risk of heart attack in a cohort of 4109 adults from Norway. The inverse association between glycine and heart attack was stronger in patients with serum apoB, LDL cholesterol, or apoA-1 levels higher than the cohort mean.
Glycine can be methylated to sarcosine by glycine N-methyltransferase (GNMT), which is mainly restricted to the liver and kidney, but is also present in aortic endothelial cells. Genetic deletion of GNMT in mice has been reported to exacerbate the development of atherosclerotic lesions, dyslipidemia and inflammation, impair reverse cholesterol transport, and increase the accumulation of oxidized LDL particles and foam cells.
Serum glycine levels are correlated with 2-hour postprandial glucose levels after oral glucose tolerance test in normal and impaired glucose tolerance adults. In addition, a clinical trial involving 8 older adults (60-75 years) reported a significant reduction in fasting blood glucose (12%; 106 to 94 mg/dL) after two weeks of supplementation with 100 mg/kg glycine (8 g/d).
A small study involving 9 healthy adults reported that 75 mg/kg of fat-free glycine-containing substances (3.6-5.4 g of glycine in total), plus 25 g of glucose, was compared with glucose alone. , was able to significantly reduce peak glucose by 15% (105 vs. 124 mg/dL), with a 50% reduction in the two-hour response in total glucose compared to glucose alone.
Similar results were obtained when glycine was combined with 130 mg/kg of leucine (5.3-8.7 g) in subsequent studies conducted in the same laboratory. That is, glycine plus leucine consumed with 25 grams of glucose reduced peak glucose by 11% and total glucose response by 66% over two hours.
The benefit of glycine in lowering postprandial blood glucose levels may be attributable to greater insulin secretion. Glycine has been reported to increase the release of glucagon-like peptide 1 (GLP-1), which enhances glucose-mediated insulin secretion. Glycine has been reported to significantly increase the insulin response to hyperglycemia during a hyperglycemic clamp when 5 grams is consumed 30 minutes earlier.
In a rat model of type II diabetes, glycine supplementation was shown to significantly reduce HbA1c, advanced glycation end product (AGE) concentrations in serum and lens, and cataract severity. Glycine has been reported to reduce glycosylation of human crystallin in vitro. Glycine reduces HbA1c and ocular lens glycosylation in an animal model of type II diabetes.
Conversely, a double-blind, randomized controlled trial including 74 men and women with type 2 diabetes reported that supplementation with 5 g of glycine per meal (15 g/day) for 3 months resulted in a significant reduction in HbA1c compared with placebo (absolute change of -1.4% vs -0.4%), as well as near significant reductions in fasting blood glucose (-23% vs -10%) and HOMA-IR (-9% vs -2%).
A single ingestion of 22.5g of glycine has been reported to significantly increase growth hormone concentrations in healthy men and women 180 minutes after ingestion. The maximum increase at 90 minutes was reported to be 3.6-fold over basal levels, with a still significant 60% increase after 180 minutes. The increase in growth hormone has a rapid onset, with a 60% increase observed within 5 minutes of ingesting glycine.
Glycine supplements, on the other hand, have been shown to reduce urinary 5-oxoproline concentrations and increase glutathione status. Together, these studies demonstrate that glutathione production and availability is sensitive to glycine status and may not be optimal when glycine is limited. Therefore, chronic glycine shortage may have long-term effects on the body’s exposure to oxidative stress.
Glycine is an essential conditional amino acid for humans. Dietary requirements are estimated at about 12 grams per day. Insufficient glycine is not life-threatening, but chronic shortages may adversely affect collagen turnover and glutathione status, potentially increasing levels of oxidative stress and the risk of bone and joint disease.
Cardiomyocytes express glycine-gated chloride channels, and administration of glycine (500 mg/kg ip) was shown to significantly reduce infarct size by 21% when rats underwent cardiac ischemia-reperfusion injury. This effect was associated with ventricular ejection fraction and fractional shortening in glycine-pretreated animals compared with controls.
Available Sizes
Size | Servings | UPC | |
---|---|---|---|
100 Veg Capsules | 100 | 733739001078 |
Suggested Usage
Take 1-3 capsules daily, preferably on an empty stomach.
Store in a cool, dry place after opening.
Caution
For adults only. Consult physician if pregnant/nursing, taking medication, or have a medical condition. Keep out of reach of children.
Glycine Supplement Facts
Serving Size: | 3 Veg Capsule |
---|---|
Servings Per Container: | 33 |
Description | Amount per Serving | % Daily Value |
---|---|---|
Glycine | 3 g (3,000 mg) | **Daily Value not established. |
**Daily Value not established. |
Other Ingredients: Hypromellose (cellulose capsule), Hydroxypropyl Cellulose, Stearic Acid (vegetable source) and Silicon Dioxide.
Not manufactured with wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Glycine Product details
Brand | Now Foods |
Format | Capsule |
Diet type | Vegetarian, Vegan |
Flavour | Unflavoured |
Product benefits | Supports Lean Muscle Growth |
Special ingredients | Amino Acid |
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